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The Unione Siciliana (often incorrectly called Unione Siciliane) was a Sicilian-American fraternal organization which eventually was rumored to have controlled much of the Italian American vote within the United States during the early twentieth century. The organization would be a major source of conflict as underworld figures who, through a series of puppet presidents largely controlled by the Chicago Outfit, fought to control the highly influential organization during Prohibition.

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