Salvatore "Sam" Genna (died December 20, 1951) was a member of the Genna crime family during Prohibition era Chicago.
Sam (Salvatore) and Peter (Pietro) Genna were the first of the six Genna brothers to arrive to Chicago in April, 1906. Sam was the political fixer of the gang, while Angelo Genna and Mike Genna were the enforcers. Angelo was also considered to be the boss of the crime family. The Genna's formed the Marsala club which linked them to their fellow countrymen who had arrived in Chicago from Marsala, province of Trapani, Sicily and exploited their fellow compatriots by making them workers in their alcohol stills and loansharking victims.
In 1925, three of the Genna brothers, Angelo, Mike and Tony Genna, were killed. After the death of Tony, the power of the Genna clan was broken. Jim, Sam, and Peter Genna fled Chicago to Sicily. Eventually, they all returned to Chicago, but lived the remainder of their lives in obscurity separating themselves from the rackets to run an olive oil importing firm.
On December 20, 1951, Salvatore "Sam" Genna, the last of the Chicago Genna brothers, died at his home at the age of 67 from a heart attack. He left a wife, two sons and a daughter.