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The Five Families are the five major Italian-American Mafia crime families which have dominated organized crime in New York City since the 1930s. The Five Families, under the suggestion of Salvatore Maranzano and Charles "Lucky" Luciano, were responsible for the establishment of The Commission, a council which demarcated territory between the previously warring factions and governs Mafia activities in the United States. The Five Families in New York remain as the powerhouse of the Sicilian Mafia in the US.

The five families and their bosses are (currently):

Bonanno: Michael Mancuso

Gambino: Domenico Cefalu

Colombo: Carmine "Junior" Persico (Andrew Russo is the acting boss)

Genovese: Daniel "Danny the Lion" Leo

Lucchese: Steven Crea

The Colombo family was once known as the Profaci Crime Family, until a coup caused a name change in the early 1960s. Former Godfather Joe Massino had wanted to change the name of the Bonanno Family to the Massino Family but since his arrest and defection it is unlikely to happen. The DeCavalcante crime family, based in nearby Elizabeth, NJ, also has ties to the five New York families.