Angelo Granelli became known as a man of business, who rarely got his owns hands dirty, unless it was a personal matter or involved a greater target. He was mysterious, and very little about him was discovered until he was arrested for narcotics. In 1946, he and Aldo Trapani conspired to eliminate the Stracci Family by destroying their explosives racket chain. It also gave Granelli the excuse to wipe out an old enemy, Stracci caporegime Oscar Zavarelle, who had assaulted his sister. He specifically gave orders for Zavarelle to be put in as much pain as possible. The plot also wiped out the entreuprenerial Leon Grossi and the Family consigliere Jack Fontana.
Granelli had planned to assist Trapani in the killing of the Stracci Underboss, Salvatore Stracci, but he was called away to other appointments involving his part in the secret regime started by Michael Corleone and run by Rocco Lampone. After the death of Salvatore in 1947, Granelli ceased his war against the Stracci Family and focused on other goals instead, some involving the narcotics trade that the secret regime was partially involved in.
He was eventually arrested for narcotics and was not freed until the early 1960s. He was present on the Corleone power structure board at the Mafia hearings in 1959.